李建,1982年6月出生,博士,教授,现任成都大学基础医学院副院长。2013年在美国俄亥俄大学获得博士学位,随后在耶鲁大学从事博士后研究。2015年回国任成都大学医学院特聘研究员。2016入选四川省特聘专家,2018入选四川省学术和技术带头人后备人选。现担任中国生物工程学会青年工作委员会委员;四川省生物化学与分子生物学会理事;四川省侨联特聘专家,四川省侨联青年工作委员会委员,成都市侨联青年工作委员会会长。已发表包括PNAS,Molecular cell,Blood,Journal of Hematology and Oncology等高水平研究论文30余篇,获得国家自然科学基金,人社部“留学回国人员科技活动择优资助”,四川省科技厅国际合作项目等资助。
主要科研项目
国家自然科学基金:DNA聚合酶zeta(Pol z)维持基因组稳定性的机制研究 (批准号:31500657), 24万,2016-2018,主持;
四川省千人计划青年人才项目, 50万,2017-2019, 主持;
人力资源社会保障部“留学回国人员科技活动择优资助”优秀类项目, DNA聚合酶zeta导致癌症化疗耐药产生的机制研究,24万,2016-2018, 主持;
四川省科技厅国际合作项目:基于合成致死效应的肾癌靶向药物研发(批准号:2017HH0097),20万, 2017-2019,主持;
四川省科技厅应用基础项目:基于TRPV1通路的卷叶贝母再生鳞茎镇咳药效物质基础研究,20万,2022-2024,主持。
代表论文
1. Jiaqing Liao, Qiuxia Lu, Zhiqi Li, Jintao Li, Qi Zhao, Jian Li* (2023) Acetaminophen-induced liver injury: Molecular mechanism and treatment from natural products. Frontiers in Pharmacology. (中科院2区,影响因子:5.6 , 通讯作者)
2. Jintao Li, Qiuxia Lu, Meihao Peng, Jiaqing Liao, Bowen Zhang, Di Zhang, Peng Huang, Yixi Yang, Qi Zhao, Bo Han,Jian Li* (2022) Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-kB pathways. Journal of Ethnopharmacology. (中科院2区,影响因子:5.4, 通讯作者)
3. Qianye Yang, Yu Li, Rong Sun, Jian Li* (2021) Identification of a RAD52 inhibitor inducing synthetic lethality in BRCA2 deficient cancer cells. Front Pharmacol. (中科院2区,影响因子: 4.225,通讯作者)
4. Yu Deng*, Wanjun Guo, Ning Xu, Fulun Li and Jian Li (2020) CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer
cells. Mol Carcinog, 59(5): p. 512-519. (中科院2区,影响因子: 3.825)
5. Rui Li, Yang Zhang, Yucheng Wang, Kejia Huang, Qianye Yang, Tiantian Zhang, Kun Xie, Jian Li* and Qi Zhao* (2020) Aqueous extract of
Fritillariae cirrhosae induces cellular apoptosis through activation of STATs-mediated immunomodulation. J Ethnopharmacol. 261:112338 (中科院2区,影响因子: 3.69,共同通讯作者)
6. Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Jian Li*, Jinming Zhang* (2019) Tetramethylpyrazine Enhances the Antitumor
Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis, Front Pharmacol. 10:707 (中科院2区,影响因子: 4.225,共同通讯作者
7. Jian Li, Wenwen Li, Kejia Huang, Yang Zhang, Gary Kupfer, Qi Zhao* (2018) Chimeric Antigen Receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward, J Hematol Oncol. 11 (1), 22 (中科院1区,影响因子:11.059, ESI 高被引论文)
8. Jun Li, and Jian Li* (2017) Can A Longer Waiting Period After Neoadjuvant Chemoradiotherapy Improve the Pathologic Complete Response Rate in Patients With Rectal Cancer?, J Clin Oncol. DOI: 10.1200/JCO.2016.69.7318 (中科院1区, 影响因子:32.956,通讯作者)
9. Jian Li #, Rong Sun#, Yuehong Wu, Minngzhu Song, Jia Li, Qianye Yang, Xiaoyi Chen, Jinku Bao*, Qi Zhao* (2017) L1198F mutation
resensitizes crizotinib to ALK by altering the conformation of inhibitor and ATP binding sites, Int. J. Mol. Sci, 18(3), 482 (中科院2区,影响因子:4.556)
10. Jian Li*, Nan Zhou, Peiling Cai, and Jinku Bao* (2016) In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment. Int. J. Mol. Sci.17, 258. (中科院2区,影响因子:4.556)
联系方式 lijian01@cdu.edu.cn