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李建
来源: 时间:2022-01-11 浏览:

李建,1982年6月出生,博士,教授,现任成都大学国际合作与交流处处长。2013年在美国俄亥俄大学获得博士学位,随后在耶鲁大学从事博士后研究。2015年回国任成都大学医学院特聘研究员。2016入选四川省特聘专家,2018入选四川省学术和技术带头人后备人选。现担任中国生物工程学会青年工作委员会委员;四川省生物化学与分子生物学会理事;四川省侨联特聘专家,四川省侨联青年工作委员会委员,成都市侨联主席。已发表包括PNAS,Molecularcell,Blood,Journal of Hematology and Oncology等高水平研究论文30余篇,获得国家自然科学基金,人社部“留学回国人员科技活动择优资助”,四川省科技厅国际合作项目等资助。

主要科研项目:

国家自然科学基金:波棱甲素抗肝纤维化直接作用靶点发现及分子机制研究(批准号:82473804),49万,2025-2028,主持;

四川省科技厅科教联合基金面上项目:抗肝纤维化天然产物波棱甲素作用机制研究及其生物工程改造(批准号:2025NSFSC2164),20万,2025-20227,主持;

国家自然科学基金:DNA聚合酶zeta(Pol z)维持基因组稳定性的机制研究 (批准号:31500657), 24万,2016-2018,主持;

四川省千人计划青年人才项目, 50万,2017-2019, 主持;

人力资源社会保障部“留学回国人员科技活动择优资助”优秀类项目, DNA聚合酶zeta导致癌症化疗耐药产生的机制研究,24万,2016-2018, 主持;

四川省科技厅国际合作项目:基于合成致死效应的肾癌靶向药物研发(批准号:2017HH0097),20万, 2017-2019,主持;

四川省科技厅应用基础项目:基于TRPV1通路的卷叶贝母再生鳞茎镇咳药效物质基础研究,20万,2022-2024,主持。

代表论文:

1. Feng Zhao, Yixi Yang, Wenyao Zhan, Zhiqi Li, Hui Yin, Jingjing Deng, Waner Li, Rui Li, Qi Zhao, Jian Li*(2024)Enjineering the bacteriophage 80 alpha endolysin as a fast and ultrasensitive detection toolbox against Staphylococcus aureus. Biosensor and Bioelectronics. (中科院1区,通讯作者)

2. Junxia Pei, Zhou Su, Xin Zeng, Ya Zhong, Yamei Zhang, Yixi Yang, Qiuxia Lu, Jian Li* & Yu Deng* (2023)Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells. BMC Complementary Medicine and Therapies.(中科院3区,通讯作者) 

3. Jiaqing Liao, Qiuxia Lu, Zhiqi Li, Jintao Li, Qi Zhao, Jian Li*(2023) Acetaminophen-induced liver injury: Molecular mechanism and treatment from natural products. Frontiers in Pharmacology. (中科院2区,通讯作者)

4. Jintao Li, Qiuxia Lu, Meihao Peng, Jiaqing Liao, Bowen Zhang, Di Zhang, Peng Huang, Yixi Yang, Qi Zhao, Bo Han,Jian Li* (2022)Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-kB pathways. Journal of Ethnopharmacology. (中科院2区,通讯作者)

5. Qianye Yang, Yu Li, Rong Sun, Jian Li* (2021) Identification of a RAD52 inhibitor inducing synthetic lethality in BRCA2 deficient cancer cells. Front Pharmacol. (中科院2区,通讯作者)

6. Yu Deng*, Wanjun Guo, Ning Xu, Fulun Li and Jian Li (2020) CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells. Mol Carcinog, 59(5): p. 512-519. (中科院2区)

7. Rui Li, Yang Zhang, Yucheng Wang, Kejia Huang, Qianye Yang, Tiantian Zhang, Kun Xie, Jian Li* and Qi Zhao* (2020) Aqueous extract of Fritillariae cirrhosae induces cellular apoptosis through activation of STATs-mediated immunomodulation. J Ethnopharmacol. 261:112338 (中科院2区,共同通讯作者)

8. Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Jian Li*, Jinming Zhang* (2019) Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis, Front Pharmacol. 10:707 (中科院2区,共同通讯作者)

9. Jian Li, Wenwen Li, Kejia Huang, Yang Zhang, Gary Kupfer, Qi Zhao* (2018) Chimeric Antigen Receptor T cell (CAR-T) immunotherapy forsolid tumors: lessons learned and strategies for moving forward, J Hematol Oncol. 11 (1), 22 (中科院1区,ESI 高被引论文)

10. Jun Li, and Jian Li* (2017) Can A Longer Waiting Period After Neoadjuvant Chemoradiotherapy Improve the Pathologic Complete Response Rate in Patients With Rectal Cancer?, J Clin Oncol. DOI: 10.1200/JCO.2016.69.7318 (中科院1区, 通讯作者)

9. Jian Li #, Rong Sun#, Yuehong Wu, Minngzhu Song, Jia Li, Qianye Yang, Xiaoyi Chen, Jinku Bao*, Qi Zhao* (2017) L1198F mutation resensitizes crizotinib to ALK by altering the conformation of inhibitor and ATP binding sites, Int. J. Mol. Sci, 18(3), 482 (中科院2区)

11. Jian Li*, Nan Zhou, Peiling Cai, and Jinku Bao* (2016) In Silico Screening Identifies a Novel Potential PARP1 Inhibitor TargetingSynthetic Lethality in Cancer Treatment. Int. J. Mol. Sci.17, 258. (中科院2区)

招生/联合招生专业:

1. 100100 基础医学(学术学位硕士)

2. 086001 生物技术与工程 (专业学位硕士)

3. 100706 药理学(学术学位硕士)

4. 105500 药学(专业学位硕士)

联系方式:lijian01@cdu.edu.cn